Sacred 2 on Windows 7

Sacred 2 Fallen Angel - patched on version 2.43 on Windows XP is running quite smoothly, but on new Windows 7 many gamers couldn't run it whatsoever.

I had run into similar problems myself - game always twitched and crushed after while.
There are some tips that helped me to run it smoothly again.

Set compatibility in properties as Windows XP SP 3* or XP SP2*.
Disable in game graphics option PhysX effects (NVidia only).

You might try also add this (if previous settings are not good enough):
Optional: disable themes, disable desktop composition, disable changes in DPI.

Run game with parameter -nocpubinding

* You don't have to check "run as Administrator", because XP compatibility mode forces it anyway.